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Life Extension Magazine

Plant Extracts That Target Fat Accumulation

target fat accumulation and fat metabolism

Aging adults tend to gain about one or two pounds every year.

And losing weight is never easy.

Scientists have identified two plant extracts that target fat accumulation and fat metabolism.

Clinical studies have shown that a patented blend of these herbal extracts, when combined with a healthy diet and a 30-minute walk, five days per week, can:

  • Reduce waist circumference by an average of 4.7 inches, and
  • Decrease hip size by an average of 4.1 inches.

Doctors frequently recommend that overweight people reduce their weight by 5% a year to achieve wide-ranging health benefits. In just 16 weeks, this patented plant extract blend reduced body weight by an average of 6.7% when combined with a healthy diet and a 30-minute walk, five days per week.

For many people, a boost like this is needed to jump-start their resolve to lose weight and cut inches from their waist and hips.

Fat-Fighting Herbal Extracts

fat fighting herbal extracts

About three quarters of the American population are overweight or obese.

The excess weight people carry around their waist is generally the most difficult to lose – and the most dangerous. Seeking a solution, scientists screened a variety of botanicals to assess their ability to promote fat loss and prevent fat accumulation.

They identified two plants used in traditional Indian medicine:

  • Sphaeranthus indicus (S. indicus) flower, and
  • Garcinia mangostana (mangosteen) fruit rind.

S. indicus is a flowering plant which has long been used in Ayurveda medicine as a nerve tonic and to treat disorders ranging from diabetes and indigestion to fever and cough.

Mangosteen is a tropical fruit that has been used in traditional medicines to treat inflammation, wounds, abdominal pain, urinary tract problems, and chronic ulcers.

In a series of clinical studies, researchers tested the impact of a patented blend of S. indicus flower extract plus mangosteen fruit rind extract on weight loss.

Help for Overweight People

help for overweight people

Scientists conducted a placebo-controlled, randomized human trial in men and women who were overweight (with an average BMI of 28.3 kg/m2).

Over the 16-week study, subjects consumed a balanced diet of approximately 2,000 calories a day. They were also instructed to walk for 30 minutes per day, five days a week.

Half of the subjects received 400 mg of the S. indicus-mangosteen blend before breakfast and dinner. The others received placebos after 4, 12, and 16 weeks, the S. indicus-mangosteen supplemented group showed significantly greater weight loss compared to the placebo group.

At 16 weeks, the average results for the group taking the herbal extracts were striking:

  • Weight was reduced by 11.2 pounds (6.7%), compared to 2.4 pounds (1.4%) for those taking placebos,
  • BMI (Body Mass Index) was reduced by 1.9 kg/m2 compared to 0.4 kg/m2 in the placebo group,
  • Waist circumference was reduced by 3.9 inches, compared to 1.5 inches in the placebo group, and
  • Hip circumference was reduced by 4.1 inches, compared to 2 inches for those taking placebos.

Impact of Sleep on Cardiovascular Risks

A recent study published online in the Journal of Preventive Cardiology analyzed data from the National Health and Nutrition Examination Survey (NHANES). A total of 17,635 eligible participants were followed for a median of 7.5 years to determine if they died from a heart attackheart failure or stroke–in other words, to determine their cardiovascular mortality.

Researchers divided participants into three groups depending on their average sleep as follows:

  1. Less than six hours,
  2. Six to seven hours, and
  3. More than seven hours.

These people were tracked to ascertain how many in each group died from cardiovascular causes. Those who slept less than six hours a night had a 45% increased risk of cardiovascular death compared to those who slept six to seven hours each night.

What confused people about this study is that it showed that those who slept more than seven hours each night also had an increased death risk. We at Life Extension received calls about this and explained that this study measured sleep duration (number of hours) and not sleep quality.

We opined that people with underlying degenerative illnesses tend to require longer sleep periods, often because their “sleep quality” is impaired.

Reduction in Obesity

Another team of scientists studied the effects of this same patented herbal blend on people who were obese, with a BMI of 30 or higher.

Over eight weeks, participants consumed a prepared diet of roughly 2,000 calories a day and walked for 30 minutes per day, five days a week.

Half of the subjects received placebo capsules, while the others received 400 mg of the S. indicus-mangosteen blend twice daily, before breakfast and dinner. Improved diet and exercise helped both groups lose weight.

The S. indicus-mangosteen supplemented group had significantly greater weight loss and dropped approximately twice as many inches from their waistline and hips than the placebo group.

After just 8 weeks, these obese individuals taking the two herbal extracts on average had their:

  • Weight reduced by 11.5 pounds, compared to 3.3 pounds for the placebo group,
  • BMI reduced by 2.2 kg/m2, compared to just 0.6 kg/m2 for those taking placebos,
  • Waist circumference reduced by 4.7 inches, compared to 2.4 inches in the placebo group, and
  • Hip size reduced by 2.5 inches, compared to 1.2 inches for subjects receiving placebos.

There were no safety issues in either of the studies, and no adverse effects were reported.


How to lose weight and fatHelp Losing Weight and Fat:

  • Many people struggle to lose weight, and even those who do find it difficult to reduce the size of their waistline.
  • A patented blend of Sphaeranthus indicus flower and mangosteen fruit rind extracts produces meaningful weight loss and significantly reduced the size of waist and hips, when combined with a balanced diet and exercise.
  • In a controlled clinical trial of overweight individuals, this patented blend of S. indicus-mangosteen extracts decreased weight by an average of 11.2 pounds, reduced waist size almost four inches on average and decreased hip size and body mass index in just 16 weeks.
  • The patented blend of S. indicus-mangosteen extracts also reduced triglyceridesLDL (“bad”) cholesterol, and total cholesterol levels, which helps improve cardiovascular health.

How the Herbal Extracts Work

help reduce fat accumulation

In vitro (laboratory) studies have been conducted showing the S. indicus-mangosteen extract blend inhibits creation of new fat cells while promoting the breakdown of existing fat cells.

These cell-based studies showed that the patented blend of S. indicus-mangosteen extracts may:

  • Reduce levels of ADRP (adipocyte differentiation-related protein), a factor that stimulates the accumulation of fat. Lowering ADRP levels inhibits fat storage.
  • Reduce levels of fatty acid synthase, an enzyme that catalyzes the synthesis of fatty acid. Lowering this enzyme inhibits the creation of new fat.
  • Inhibit expression of perilipin, a protein that coats fat droplets and keeps them from being broken down. Reducing perilipin allows fat to be broken down more easily.
  • Decrease expression of PPAR-gamma, a metabolic “sensor” that triggers fat storage and production of new adipose cells. Lowering PPAR-gamma expression helps prevent fat from accumulating.

Together, these actions help reduce fat accumulation and spur fat breakdown, potentially explaining the weight and waistline reductions seen in human trials.

Improved Cardiovascular Markers

improved cardiovascular markers

The benefits of this patented blend of S. indicus-mangosteen extracts go further. In the study of overweight individuals, researchers noted an improvement in lipid measurements, critical markers of cardiovascular health.

Levels of dangerous triglycerides and VLDL (very low-density lipoprotein cholesterol) that were elevated at the start of the study dropped almost to the normal range. Overall cholesterol and LDL were also reduced.

In just 16 weeks, and compared to placebo, subjects taking the dual-patented blend on average had their:

  • Triglycerides decreased by 22%,
  • Cholesterol decreased by 12%,
  • LDL (“bad”) cholesterol decreased by 16%,
  • VLDL cholesterol decreased by 19%,
  • HDL (“good”) cholesterol increased by 6%, and
  • LDL/HDL ratio decreased by 18%.

Together with the reduction in body weight, these changes in blood lipids can provide additional protection against an array of cardiovascular disorders and other vascular disorders.


health benefits of a reducing weight

Setting unrealistically high goals can doom any weight-loss program.

Experts agree that losing just a few pounds can make a huge difference, and many point to the substantial benefits of a reasonable and achievable 5% reduction in weight.

Evidence shows that decreasing your weight by only 5% may:

  • Protect knee joints and reduce the risk of osteoarthritis of the knee,
  • Help prevent or delay type II diabetes,
  • Help diabetics control blood sugar and inhibit diabetes-related conditions,
  • Increase levels of protective HDL cholesterol, lowering the risk of heart disease,
  • Decrease levels of triglycerides, reducing the risk of heart attack or stroke,
  • Lower systolic blood pressure by about five points,
  • Improve sleep and reduce sleep apnea, and
  • Help reverse insulin resistance.

In controlled clinical studies, people who took a patented blend of S. indicus and mangosteen extracts lost an average of between 6.4% and 6.7% of their body weight, when combined with a balanced diet and exercise.


overweight or obese poses serious health risks

Being overweight or obese poses serious health risks. Excess weight around the waist is especially dangerous.

Scientists have identified two plant extracts that, when combined in a specific ratio, decrease weight by an average 6.7% within 16 weeks, when combined with a balanced diet and regular exercise.

In controlled clinical trials, this patented blend of S. indicus flower and mangosteen fruit rind not only produced meaningful weight loss, but also substantially decreased the size of waist and hips.

In an additional benefit, artery-clogging blood lipid levels improved significantly, providing extra benefits for heart health.

If you have any questions on the scientific content of this article, please call a Life Extension® Wellness Specialist at +1-866-864-3027.

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